Obesity and Central Obesity are Associated with an Increased Risk of Colorectal Cancer, Research Says

persons with two types of body shapes had a higher risk of developing colorectal cancer than persons with other body types, according to study from a big multinational team of medical researchers.

The scientists evaluated thousands of people’s genetic predispositions and body shapes for the risk of colorectal cancer in their study, which was published in the journal Science Advances.

The colon or rectum is where colorectal tumors begin to grow. About 150,000 cases of colorectal cancer are diagnosed annually, making it the second most common cause of cancer-related deaths in the United States, according to earlier studies. Although there are additional factors that influence the likelihood of having the condition, chiefly lifestyle decisions, the lifetime risk for the disease is 1 in 25 for women and 1 in 23 for men.

A different group of researchers discovered data in 2016 that connected central obesity in tall individuals and obesity in general to an increased risk of colorectal cancer. With a far bigger sample size in this new endeavor, the study team conducted comparable studies.

This was the largest study of its sort to date, involving the collection and analysis of data from 550,000 adult U.K. Biobank documents. Additionally, they examined genetic information gleaned from tissue samples taken from eight hundred more donors.

The study team discovered that tall individuals with “apple” shapes—those with a genetic predisposition to gain weight around the middle—had a higher risk of colorectal cancer than those with other body types with different genetic codes. They discovered that tall, apple-shaped people also had a higher likelihood of digestive system-related illnesses.

Individuals with genes that increased their risk of obesity from an improper diet were also more vulnerable to the illness. They also observed that distinct biochemical pathways, fueled by specific genetic patterns, led to the disease in the two body types.

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